40w LaterGuide

Active ingredients: Ethinyl estradiol + drospirenone
Form: Oral tablet

Pills containing both drospirenone and ethinyl estradiol are a type of combined oral contraceptive (COC).

In some countries, COCs containing drospirenone are described as “fourth-generation” pills. However, this classification is not used consistently worldwide. The specific hormones and doses, along with individual health conditions and risk factors, are more important when choosing a contraceptive.

Can they be used for reasons other than contraception?

Combined oral contraceptives can make bleeding patterns more predictable and may reduce menstrual bleeding and period pain. They may also be used to manage irregular periods associated with conditions such as PCOS.

However, birth control pills do not treat irregular ovulation to improve the chance of pregnancy. Because they suppress ovulation while being taken, people who are currently trying to conceive may need a different evaluation or treatment.

What is special about drospirenone?

Drospirenone has antiandrogenic and antimineralocorticoid properties. Some COCs containing drospirenone are also used to treat conditions such as acne or premenstrual dysphoric disorder (PMDD), depending on the product and country.

What is different about fourth-generation pills?

The generation labels mainly reflect the type of progestin used. Their contraceptive effectiveness is generally similar, but their side-effect and risk profiles can differ.

COCs containing drospirenone are associated with a higher risk of venous thromboembolism (VTE) than COCs containing levonorgestrel. However, the absolute risk remains low, and individual risk depends on factors such as age, smoking, body weight, and personal or family history of blood clots.

No single generation is best for everyone.